Dithiocarbamates Induce Craniofacial Abnormalities and Downregulate sox9a during Zebrafish Development
نویسندگان
چکیده
منابع مشابه
Mutations affecting craniofacial development in zebrafish.
In a large-scale screen for mutations affecting embryogenesis in zebrafish, we identified 48 mutations in 34 genetic loci specifically affecting craniofacial development. Mutants were analyzed for abnormalities in the cartilaginous head skeleton. Further, the expression of marker genes was studied to investigate potential abnormalities in mutant rhombencephalon, neural crest, and pharyngeal end...
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The zebrafish, Danio rerio, is a small, freshwater teleost that only began to be used as a vertebrate genetic model by the late George Streisinger in the early 1980s. The strengths of the zebrafish complement genetic studies in mice and embryological studies in avians. Its advantages include high fecundity, externally fertilized eggs and transparent embryos that can be easily manipulated, inexp...
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(i) Retinoids and embryopathy Comments focussed primarily on the differential teratogenicity of the various retinoids used experimentally and on the dose levels concerned. Dr Johnston raised the issue of retinoid blood levels following application of retinol to embryos. Studies by Kochhar in the seventies using radiolabelled retinol showed that the blood levels went up to a high peak following ...
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The role of Anti-Müllerian hormone (Amh) during gonad development has been studied extensively in mammals, but is less well understood in other vertebrates. In male mammalian embryos, Sox9 activates expression of Amh, which initiates the regression of the Mullerian ducts and inhibits the expression of aromatase (Cyp19a1), the enzyme that converts androgens to estrogens. To better understand sha...
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Symmetr y and propor t ion plays an impor tan t role in cosmeti c par t of face and golden ra tio depicts a st rong cor rela tion between mathematical propor t ion of face and appearance. Th is can be a ffected by mult iple fa ctor s including syndromes which con tr ibute a sign ifican t role in cran iofacial abnormali ties. Th is paper in tends to br ing out the craniofacial man ifesta t ions ...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2010
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfq169